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ACROBiosystems Mouse CD3 epsilon Protein, Fc Tag
Marke: ACROBiosystems CDE-M5256-100UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 36 kDa. The protein migrates as 40-43 kDa under reducing (R) condition (SDS-PAGE).Spezifikation
| 36 kDa | |
| Mouse CD3E, Fc Tag (CDE-M5256) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Asp 108 (Accession # P22646). | |
| -20°C | |
| CD3 epsilon | |
| Mouse | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |
| 100 μg | |
| Asp 23 - Asp 108 | |
| FLJ18683,T3E,TCRE,CD3E,CD3-epsilon | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |