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ACROBiosystems Human IL-33 Protein, His Tag
Marke: ACROBiosystems IL3-H52H7-1mg
Weitere Details : Netto-Gewicht : 0.00010kg
Description
Interleukin 33 (IL33) is known as C9orf26, DKFZp586H0523, DVS27, NF-HEV, NFEHEV, RP11-575C20.2,and is a cytokine belonging to the IL-1 superfamily. IL-33 induces helper T cells, mast cells, eosinophils and basophils to produce type 2 cytokines. IL-33 mediates its biological effects by interacting with the receptors ST2 (aka IL1RL1) and IL-1 Receptor Accessory Protein (IL1RAP), activating intracellular molecules in the NF-κB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-5 and IL-13) from polarized Th2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 20.2 kDa. The protein migrates as 25-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spécification
| AAH47085.1 | |
| 1 mg | |
| His 109 - Thr 270 | |
| IL33,DV27,C9ORF26,IL1F11,NFHEV,DKFZp586H0523,DVS27,NFEHEV,RP11-575C20.2 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 20.2 kDa | |
| Human IL-33, His Tag (IL3-H52H7) is expressed from human 293 cells (HEK293). It contains AA His 109 - Thr 270 (Accession # O95760-1). | |
| -20°C | |
| IL-33 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Cytokines and Growth Factors |