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AP50 Mouse, Unlabeled, Clone: 31, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 611350

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15885889

  • 329.46 € / 1 Set
Verfügbar ab: 02-01-2023
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Beschreibung

Beschreibung

Sorting of integral membrane proteins is mediated vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large adaptin proteins (γ, α, δ, ε, and β1, β2, β3, β4 respectively) that are noncovalently linked to one medium chain (μ1, μ2, μ3, μ4 respectively) and one small chain ( σ1, σ2, σ3, σ4 respectively). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2, μ2 (AP50) interacts with integral membrane proteins via binding to tyrosine-based signals with the canonical motif YXXφ. In addition, AP50/μ2 is required for both the assembly and the proton transport activity of vacuolar (H+)-ATPases in clathrin coated vesicles. Thus, AP50/μ2 may be involved in targeting integral membrane proteins that are sorted based on tyrosine-based signals and involved in assembly of functional ion channels associated with clathrin coated vesicles.

Host Species: Mouse
Clone: 31
Isotype: IgG1
Species Reactivity: Rat
Immunogen: Mouse AP50/μ2 aa. 110-230
Formula Weight [Chemical]: 50kDa

Immunofluorescence, Western Blotting

Spezifikation

Spezifikation

AP50
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Mouse AP50/μ2 aa. 110-230
50 μg
Cell Biology
Rat, Mouse, Human
IgG1
Western Blot
31
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.