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Cdk1 Mouse, Unlabeled, Clone: 1, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 610038
Weitere Details : Netto-Gewicht : 0.01000kg
Beschreibung
Cdk1, also known as p34 [cdc2], is a ubiquitously expressed serine/threonine protein kinase. Cdk1/cdc2 has been identified as the catalytic subunit of the maturation-promoting factor (MPF), while cyclin B acts as the regulatory subunit. The binding of these two subunits is critical to the transition into M-phase of the mammalian cell cycle, and this factor's role is regulated by a series of phosphorylations and dephosphorylations. After binding to cyclin B, cdk1/cdc2 is phosphorylated on Thr-14, by Myt1, and Tyr-15, by wee1 or mik1, yielding an inactive pre-MPF complex. Phosphorylation of cdk1/cdc2 on Thr-161 is performed by a cdk7/cyclin H complex and is necessary for activation of the cdc2 complex. Dephosphorylation of Thr-14 and Tyr-15 by CDC25 occurs at the prophase/metaphase transition and completes activation of the cdc2/cyclin B complex, initiating the cell's entry into mitosis.Spezifikation
Cdk1 | |
Monoclonal | |
250μg/mL | |
Cdc2, p34 | |
Mouse | |
Affinity Purified | |
RUO | |
Primary | |
Store undiluted at -20°C. |
Western Blot | |
1 | |
Unconjugated | |
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
Human p34 [cdc2] aa. 283 to 297 | |
150 μg | |
Cell Biology | |
Human, Mouse, Rat | |
IgG1 |
For Research Use Only.