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PI4-Kinase β Mouse, Unlabeled, Clone: 7, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 611817

Weitere Details : Netto-Gewicht : 0.01100kg

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Artikelnummer. 15896029

  • 647.52 € / 1 Set
Verfügbar ab: 28-12-2022
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Beschreibung

Beschreibung

Phosphoinositide turnover is a well established mechanism of intracellular signal transduction. Sequential phosphorylation of phosphatidylinositol (PtdIns) results inPtdIns-4-phosphate (PIP) and PtdIns-4,5-bisphosphate (PIP2). Phospholipase C (PLC)hydrolyzes PIP2 to inositol-1,4,5-trisphosphate (IP3) which stimulates release of intracellular Ca2+. PIP is generated by phosphorylation of PtdIns at the D4 position of the inositol ring. This event is mediated by the PtdIns 4-kinases (PI4-K). These enzymes are divided into two types (II and III) based on their size and sensitivity to certain compounds. Although the PI4-Ks are abundantly distributed throughout the cell, activity is found primarily in association with membranous structures. Members of this family contain a lipid kinase unique domain and a C-terminal catalytic domain. Two mammalian PI4-Ks, PI4-Kα and PI4-Kβ, have been identified. PI4-Kβ is homologous to the yeast PI4-K, PIK1. Based on its size and sensitivity to wortmanin (a PI3-K inhibitor), PI4-Kβ is classified as a type III enzyme. Although it is found in the cytosol and in association with the Golgi, the specific function of PI4-Kβ is yet to be determined.

Host Species: Mouse
Clone: 7
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human PI4Kβ aa. 411-626

Immunofluorescence, Western Blotting

Spezifikation

Spezifikation

PI4-Kinase β
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human PI4Kβ aa. 411-626
150 μg
Cell Biology
Rat, Mouse, Human, Canine
IgG2a
Western Blot
7
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.