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PKA [RI] Mouse, Unlabeled, Clone: 18, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 610166

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15885299

  • 596.22 € / 1 Set
Verfügbar ab: 03-01-2023
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Beschreibung

Beschreibung

cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ. These subunits define type I and II cAMP-dependent protein kinases. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and type II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ). Type II PKA can be distinguished by autophosphorylation of the R-subunits, while type I PKA binds Mg/ATP with high affinity. Most cells express both type I and type II PKAs. Although the Rα isoforms are ubiquitously expressed, the Rβ isoforms are predominant in nervous and adipose tissues. The levels of expression of the different subunits vary according to cell and tissue type.

Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting

Spezifikation

Spezifikation

PKA [RI]
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
and ≤0.09% sodium azide., glycerol, Aqueous buffered solution containing BSA
150 μg
Cell Biology
Rat, Mouse, Human, Frog, Chicken, Canine
IgG2b
Western Blot
18
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.