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PKA RIIβ Mouse, Unlabeled, Clone: 45, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 610626

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15885549

  • 696.54 € / 1 Set
Verfügbar ab: 23-12-2022
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Beschreibung

Beschreibung

cAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RIα, RIβ, RIIα, and RIIβ.These subunits define type I and II cAMP-dependent protein kinases. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and type II holoenzymes have three potential C subunits (Cα, Cβ, or Cγ). Type II PKA can be distinguished by autophosphorylation of the R-subunits, while type I PKA binds Mg/ATP with high affinity. Most cells express both type I and type II PKAs. Although the Rα isoforms are ubiquitously expressed, the Rβ isoforms are predominant in nervous and adipose tissues. There are indications that the deletion of the gene for PKA RIIβ results in lack of long-term potentiation in a select group of hippocampal cells, suggesting an important role for this protein in the neurosciences.

Immunofluorescence, Immunoprecipitation, Western Blotting

Spezifikation

Spezifikation

PKA RIIβ
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
aa 1-418, Human PKA RIIβ
150 μg
Cell Biology
Rat, Mouse, Human, Chicken, Canine
IgG1
Western Blot
45
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.