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Stat6 Mouse, Unlabeled, Clone: 23/STAT6, BD

Mouse Monoclonal Antibody

Marke:  BD Biosciences 611290

Weitere Details : Netto-Gewicht : 0.01100kg

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Artikelnummer. 15895859

  • 320.34 € / 1 Set
Verfügbar ab: 19-12-2022
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Beschreibung

Beschreibung

STATs (signal transducers and activators of transcription) are critical mediators of the biologic activity of cytokines including Interleukins (IL) 2-5, IL-7, IL-15, GM-CSF, erythropoietin and growth hormone. Ligand-receptor interaction leads to activation of constitutively associated JAK family kinases and subsequent recruitment/activation of STATs by tyrosine phosphorylation. Active STATs then move to the nucleus to promote transcription of cytokine-inducible genes. Seven STAT proteins have been cloned, each of which is differentially expressed and/or activated in a cytokine-specific and cell type-specific manner. Stat6 plays an important role in signaling pathways that lead to the differentiation of T helper type 2 (Th2) cells from uncommitted CD4 T cell precursors. Moreover, IL-4, secreted by activated T lymphocytes, basophils, and mast cells, induces specific gene expression via the induction of tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.

Host Species: Mouse
Clone: 23
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Stat6 C-terminal Recombinant Protein
Formula Weight [Chemical]: 100kDa

Immunofluorescence, Western Blotting

Spezifikation

Spezifikation

Stat6
Monoclonal
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Human Stat6 C-terminal Recombinant Protein
50 μg
Cell Biology
Rat, Mouse, Human
IgG1
Western Blot
23/STAT6
Unconjugated
Mouse
Affinity Purified
RUO
Primary
Store undiluted at -20°C.
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Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate
Sonderangebote

Sonderangebote

For Research Use Only.