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ACROBiosystems Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, Fc, Avitag™
Biotinylated Protein
Marke: ACROBiosystems GUC-H82F8-25ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 74.1 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
NP_004954.2 | |
25 μg | |
Ser 24 - Gln 430 | |
GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C | |
Precision Avi | |
Fc Tag and Avi Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |
74.1 kDa | |
Biotinylated Human GUCY2C, Fc,Avitag (GUC-H82F8) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1). | |
-20°C | |
GUCY2C | |
Human | |
PBS, pH7.4 | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |