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ACROBiosystems Biotinylated Human GUCY2C / Guanylyl cyclase C Protein, Fc, Avitag™
Biotinylated Protein
423.38 € - 1862.87 €
Spezifikation
| Zugriffsnummer | NP_004954.2 |
|---|---|
| Molekulargewicht | 74.1 kDa |
| Quelle | Biotinylated Human GUCY2C, Fc,Avitag (GUC-H82F8) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1). |
| Immunogen | Ser 24 - Gln 430 |
| Lagerungsbedingungen | -20°C |
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
|---|---|---|---|---|---|---|---|---|---|
| Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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17156351
|
ACROBiosystems
GUC-H82F8-200UG |
200 μg |
1862.87 €
200 Mikrogramm |
Verfügbar ab: 07-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
|
17166351
|
ACROBiosystems
GUC-H82F8-25UG |
25 μg |
423.38 €
25 Mikrogramm |
Verfügbar ab: 07-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a Avi tag (Avitag™). The protein has a calculated MW of 74.1 kDa. The protein migrates as 90-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_004954.2 | |
| Biotinylated Human GUCY2C, Fc,Avitag (GUC-H82F8) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # P25092-1). | |
| -20°C | |
| GUCY2C | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| MABSol™ Biotin Labeled Proteins |
| 74.1 kDa | |
| Ser 24 - Gln 430 | |
| GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C | |
| Precision Avi | |
| Fc Tag and Avi Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |