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CD161 Mouse anti-Human, PE, Clone: DX12, BD
Mouse Monoclonal Antibody
Marke: BD Biosciences 556081
Weitere Details : Netto-Gewicht : 0.02000kg
Beschreibung
The DX12 monoclonal antibody specifically binds to human CD161 which is also known as Natural killer cell surface protein P1A (NKR-P1A). CD161 is encoded by the KLRB1 (Killer cell lectin-like receptor subfamily B member 1) gene. CD161 is a member of the C-type lectin superfamily and is also referred to as C-type lectin domain family 5 member B (CLEC5B). CD161 is a 80 kDa disulfide-linked homodimer, type II membrane glycoprotein. CD161 is expressed mostly on NK cell populations and on subsets of CD4+ and CD8+ αβ T cells, NKT cells and γδ T cells. Reports indicate that CD161 is expressed preferentially on CD45RO+ T cells, however, it can be found on a subset of thymocytes and fetal liver T cells. Its function has not been fully elucidated, but reports indicate that NKR-P1A may serve as a specific receptor for some NK cell targets. The DX12 antibody can reportedly inhibit spontaneous cytotoxicity mediated by certain NK cell clones.
Spezifikation
| CD161 | |
| Monoclonal | |
| PE | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
| Flow Cytometry | |
| DX12 | |
| Aqueous buffered solution containing BSA and ≤0.09% sodium azide. | |
| Human NKR-P1A Transfected Mouse Fibroblasts | |
| 100 Tests | |
| Immunology | |
| Human | |
| IgG1 κ |
For Research Use Only.