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ACROBiosystems Human B7-H3 / CD276 Protein, Fc Tag
MALS verified
Marke: ACROBiosystems B73-H5253-100UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.9 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
49.9 kDa | |
Human B7-H3, Fc Tag (B73-H5253) is expressed from human 293 cells (HEK293). It contains AA Leu 29 - Pro 245 (Accession # Q5ZPR3-2). | |
-20°C | |
B7-H3 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Immune Checkpoint Proteins |
100 μg | |
Leu 29 - Pro 245 | |
B7-H3,CD276,B7 homolog 3 | |
Unconjugated | |
Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |