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ACROBiosystems Human Dkk-3 (R335G) Protein, His Tag

143.96 € - 515.86 €

Spezifikation

Zugriffsnummer NP_001018067.1 (R335G)
Molekulargewicht 37.0 kDa
Quelle Human Dkk-3 (R335G), His Tag (DK3-H5220) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Ile 350 (Accession # Q9UBP4-1 (R335G)).
Immunogen Ala 22 - Ile 350
Lagerungsbedingungen -20°C
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
15896567
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ACROBiosystems
DK3-H5220-200UG
200 μg
515.86 €
200 Mikrogramm
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Verfügbar ab: 08-04-2024
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15806577
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ACROBiosystems
DK3-H5220-20UG
20 μg
143.96 €
20 Mikrogramm
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Verfügbar ab: 08-04-2024
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Beschreibung

Beschreibung

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.0 kDa. The protein migrates as 45-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_001018067.1 (R335G)
Human Dkk-3 (R335G), His Tag (DK3-H5220) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Ile 350 (Accession # Q9UBP4-1 (R335G)).
-20°C
Dkk-3
Human
PBS, pH7.4
HEK293
Bio-Markers and CD Antigens
37.0 kDa
Ala 22 - Ile 350
DKK3,REIC,RIG
Unconjugated
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

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