missing translation for 'onlineSavingsMsg'
Learn More
Learn More
ACROBiosystems Human IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free
Marke: ACROBiosystems ILB-H52W5-1MG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Human IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23 alpha and IL-12 beta, has a calculated MW of 19.5 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta). Subunit IL-23 alpha is fused with a polyhistidine tag at the N-terSpezifikation
| NP_057668.1 (IL23A) and NP_002178.2 (IL12B) | |
| 1 mg | |
| Arg 20 - Pro 189 (IL23A) and Ile 23 - Ser 328 (IL12B) | |
| IL-23 alpha and IL-12 beta | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 19.5 kDa (IL23A) and 34.7 kDa (IL12B) | |
| Human IL-23 A&IL-12; B Heterodimer Protein, His Tag&Tag; Free (ILB-H52W5) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 189 (IL23A) and Ile 23 - Ser 328 (IL12B) (Accession # Q9NPF7-1 (IL23A) and P29460-1 (IL12B)). | |
| -20°C | |
| IL23A and IL12B | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Cytokines and Growth Factors |