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ACROBiosystems Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein, His Tag&Tag Free

Marke:  ACROBiosystems IT7-H52W4-1MG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15887157

  • 3615.28 € / 1 Milligramm
Verfügbar ab: 02-01-2023
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Beschreibung

Beschreibung

Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer’s patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).

Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 111.4 kDa (ITGA4) and 81.8 kDa (ITGB7). Subunit ITGA4 is fused with an acidic tail at the C-terminus and followed by a polyhistid
Spezifikation

Spezifikation

NP 000876.3 (ITGA4) and NP_000880.1 (ITGB7)
111.4 kDa (ITGA4) and 81.8 kDa (ITGB7)
1 mg
Tyr 34 - Thr 977 (ITGA4) and Glu 20 - His 723 (ITGB7)
Integrin alpha 4 beta 7,ITGA4andITGB7
Unconjugated
50 mM Tris, 100 mM NaCl, pH7.5
HEK293
Human
Powder
>90% as determined by SDS-PAGE
Human ITGA4&ITGB7; Heterodimer Protein, His Tag&Tag; Free (IT7-H52W4) is expressed from human 293 cells (HEK293). It contains AA Tyr 34 - Thr 977 (ITGA4) and Glu 20 - His 723 (ITGB7) (Accession # P13612-1 (ITGA4) and P26010-1 (ITGB7)).
-20°C
Integrin alpha 4 beta 7
His Tag
Less than 1.0 EU / µg by the LAL method.
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