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ACROBiosystems Human M-CSF R / CSF1R / CD115 Protein, Mouse IgG2a Fc Tag

MALS verified

362.89 € - 2661.24 €

Spezifikation

Zugriffsnummer NP_005202.2
Molekulargewicht 81.4 kDa
Quelle Human M-CSF R, Mouse IgG2a Fc Tag (MALS verified) (CSR-H5255) is expressed from human 293 cells (HEK293). It contains AA Ile 20 - Glu 512 (Accession # P07333-1).
Immunogen Ile 20 - Glu 512
Lagerungsbedingungen -20°C
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
17136261
Unterlagen ansehen Aktionsdetails
ACROBiosystems
CSR-H5255-1MG
1 mg
2661.24 €
1 Milligramm
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Verfügbar ab: 24-05-2024
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17126261
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ACROBiosystems
CSR-H5255-100UG
100 μg
362.89 €
100 Mikrogramm
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Verfügbar ab: 24-05-2024
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Beschreibung

Beschreibung

Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeIII subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 81.4 kDa. The protein migrates as 105-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_005202.2
Human M-CSF R, Mouse IgG2a Fc Tag (MALS verified) (CSR-H5255) is expressed from human 293 cells (HEK293). It contains AA Ile 20 - Glu 512 (Accession # P07333-1).
-20°C
M-CSF R
Human
PBS, pH7.4
HEK293
Bio-Markers and CD Antigens
81.4 kDa
Ile 20 - Glu 512
CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
Unconjugated
Mouse IgG Fc Tag
Less than 0.1 EU / μg by the LAL method.
Powder
>90% as determined by SDS-PAGE
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Produktzertifizierungen