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Abnova™ Human SLC4A1 Partial ORF (NP_000333.1, 261 a.a. - 360 a.a.) Recombinant Protein with GST-tag at N-terminal

Used for AP, Array, ELISA, WB-Re

335.00 € - 508.00 €

Spezifikation

Zugriffsnummer NP_000333.1
Zur Verwendung mit (Anwendung) Antibody Production, ELISA, Protein Array, Western Blot
Zusammensetzung 50mM Tris-HCI, 10mM reduced Glutathione, pH=8.0 in the elution buffer.
Gen-ID (Entrez) 6521
Molekulargewicht 36.74kDa
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Produkte 2
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
Produktcode Marke Menge Preis Menge & Verfügbarkeit  
16175385
Unterlagen ansehen Aktionsdetails
Abnova™
H00006521-Q01.25UG
25 ug
508.00 €
25 Mikrogramm
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Verfügbar ab: 10-05-2024
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16165385
Unterlagen ansehen Aktionsdetails
Abnova™
H00006521-Q01.10UG
10 ug
335.00 €
10 Mikrogramm
Alternative Produkte anzeigen
Sparen Sie bis zu 
»
Verfügbar ab: 10-05-2024
Sie sich ein, um den Lagerbestand zu sehen
Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!
Beschreibung

Beschreibung

The protein encoded by this gene is part of anion exchanger family and is expressed in erythrocyte plasma mem, where it functions as a chloride/bicarbonate exchanger involved in CO2 transport from tissues to lungs. The protein comprises 2 distinct domains. The N-terminal 40kDa domain is located in cytoplasm and acts as an attachment site for red cell skeleton by binding ankyrin. The glycosylated C-terminal memb-associated domain contains 12-14 memb spanning segments and carries out stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the memb domain binds carbonic anhydrase II. The encoded protein associates with the red cell memb protein glycophorin A which promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, lead to 2 types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis results from heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.

Sequence: PIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYK
Spezifikation

Spezifikation

NP_000333.1
50mM Tris-HCI, 10mM reduced Glutathione, pH=8.0 in the elution buffer.
36.74kDa
12.5% SDS-PAGE Stained with Coomassie Blue.
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
AE1/BND3/CD233/DI/EMPB3/EPB3/FR/MGC116750/MGC116753/MGC126619/MGC126623/RTA1A/SW/WD/WD1/WR
SLC4A1
Recombinant
wheat germ expression system
Antibody Production, ELISA, Protein Array, Western Blot
6521
SLC4A1 (Human) Recombinant Protein (Q01)
PIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYK
RUO
SLC4A1
Wheat Germ (in vitro)
GST
Liquid
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Produktzertifizierungen