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JMY Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 25098-1-AP-20UL

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 16883635

  • 140.00 € / 20 Mikroliter
Verfügbar ab: 08-05-2024
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Beschreibung

Beschreibung

JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Spezifikation

Spezifikation

JMY
Polyclonal
Unconjugated
JMY
JMY, WHDC1L3
Rabbit
Antigen Affinity Chromatography
RUO
133746, 57748, 683593
-20°C
Liquid
Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Western Blot
0.43 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8N9B5, Q9QXM1
Jmy
JMY Fusion Protein Ag18735
20 μL
Primary
Mouse, Rat, Human
Antibody
IgG
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote