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JMY Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marke:  Proteintech 25098-1-AP-20UL

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 16883635

  • 112.71 € / 20 Mikroliter

Verfügbar ab
16-06-2021

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Beschreibung

Beschreibung

JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.
Spezifikation

Spezifikation

JMY
0.43 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Q8N9B5, Q9QXM1
JMY, WHDC1L3
Rabbit
IgG
20 μL
-20°C
Primary
133746, 57748, 683593
Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Western Blot
Unconjugated
JMY
Liquid
Jmy
JMY Fusion Protein Ag18735
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Mouse, Rat, Human
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation