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JMY Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marke: Proteintech 25098-1-AP-20UL
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
JMY acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.Spezifikation
JMY | |
Polyclonal | |
Unconjugated | |
JMY | |
JMY, WHDC1L3 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
133746, 57748, 683593 | |
-20°C | |
Liquid |
Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Western Blot | |
0.43 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
Q8N9B5, Q9QXM1 | |
Jmy | |
JMY Fusion Protein Ag18735 | |
20 μL | |
Primary | |
Mouse, Rat, Human | |
Antibody | |
IgG |