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Invitrogen™ Human MAP4K3 (GLK), GST Tag Recombinant Protein

Human MAP4K3 (GLK), GST Tag Recombinant Protein

Marke:  Invitrogen™ PV6350

Weitere Details : Netto-Gewicht : 0.01000kg

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Artikelnummer. 15468983

  • 1656.00 € / 100 Mikrogramm
Verfügbar ab: 04-06-2024
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Beschreibung

Beschreibung

MAP4K3 (also known as GLK) is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. MAP4K3 is upstream of the MEKK1 target and is stimulated by UV radiation and TNF-alpha and can lead to the activation of the JNK signaling pathway. MAP4K3 can directly activate PKC-Θ, during TCR signaling and people with systemic lupus erythematosus show considerable enhanced MAP4K3 expression and activation of PKC-Θ, and the kinase IKK in T cells. MAP4K3 can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted posttranscriptional modulation of PUMA, BAD, and BIM. Recombinant human MAP4K3 (1-380) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

  • Validated in LanthaScreen™ Kinase Binding Assay
  • Protocols available for simple use and optimized performance
  • Multiple pack sizes available for convenient use

    Related Product:
    LanthaScreen™ Eu Kinase Binding Assay
  • Spezifikation

    Spezifikation

    Kinase Assay
    100 μg
    aa 1-380
    Recombinant
    Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol

    Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws.
    Baculovirus
    Recombinant, Fragment
    69.6 kDa
    MAP4K3, MAPKKKK3, MEKKK3, RAB8IPL1
    Human
    GST Tag
    Serine/Threonine Kinase
    Kinases & Inhibitors
    Liquid
    Produktvorschläge

    Produktvorschläge

    Videos
    Sicherheitsdatenblatt (SDS)
    Dokumentation

    Dokumentation

    Zertifikate
    Sonderangebote

    Sonderangebote