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ACROBiosystems Mouse IL-4 R alpha / CD124 Protein, Fc Tag

Marke:  ACROBiosystems ILR-M5252-100UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15897127

  • 296.52 € / 100 Mikrogramm
Verfügbar ab: 05-01-2023
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Beschreibung

Beschreibung

IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132). Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-­biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL­13Ra1 to form the type II receptor which is responsive to both IL­4 and IL­13. Interleukin-4 receptor has been shown to interact with SHC1.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE).
Spezifikation

Spezifikation

NP_001008700
51 kDa
100 µg
Ile 26 - Arg 233
IL4R,CD124,IL4RA
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Mouse
Powder
>95% as determined by SDS-PAGE
Mouse IL-4 R alpha, Fc Tag (ILR-M5252) is expressed from human 293 cells (HEK293). It contains AA Ile 26 - Arg 233 (Accession # NP_001008700).
-20°C
IL-4 R alpha
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
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