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ACROBiosystems Rhesus macaque LAIR-1 / CD305 Protein, Mouse IgG2a Fc Tag
423.38 € - 3108.82 €
Spezifikation
Molekulargewicht | 42.9 kDa |
---|---|
Quelle | Rhesus macaque LAIR-1, Mouse IgG2a Fc Tag (LA1-C52A3) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Try 165 (Accession # ALV66454.1). |
Immunogen | Gln 22 - Try 165 |
Lagerungsbedingungen | -20°C |
Gen-Alias | LAIR1,CD305 |
Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
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Produktcode | Marke | Menge | Preis | Menge & Verfügbarkeit | |||||
15857197
|
ACROBiosystems
LA1-C52A3-100UG |
100 μg |
423.38 €
100 Mikrogramm |
Verfügbar ab: 08-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
16457819
|
ACROBiosystems
LA1-C52A3-1MG |
1 mg |
3108.82 €
1 Milligramm |
Verfügbar ab: 08-05-2024 Loggen Sie sich ein, um den Lagerbestand zu sehen |
Bitte melden Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute! | ||||
Beschreibung
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 42.9 kDa. The protein migrates as 64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
42.9 kDa | |
Gln 22 - Try 165 | |
LAIR1,CD305 | |
Unconjugated | |
Mouse IgG Fc Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |
Rhesus macaque LAIR-1, Mouse IgG2a Fc Tag (LA1-C52A3) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Try 165 (Accession # ALV66454.1). | |
-20°C | |
LAIR-1 | |
Rhesus Macaque | |
Tris with Glycine, Arginine and NaCl, pH7.5 | |
HEK293 | |
Immune Checkpoint Proteins |