Pyrimidine und Derivate

Aromatische organische Verbindungen, die aus einem aromatischen sechsgliedrigen Ring bestehen, der zwei nicht benachbarte Stickstoffatome und vier Kohlenstoffatome enthält; enthalten Verbindungen, die aus Pyrimidinen abgeleitet werden.

1 – 15 von 475 Ergebnisse

Thermo Scientific Chemicals Uracil, ≥ 99 %

CAS: 66-22-8 Summenformel: C4H4N2O2 Molekulargewicht (g/mol): 112.09 MDL-Nummer: MFCD00006016 InChI-Schlüssel: ISAKRJDGNUQOIC-UHFFFAOYSA-N Synonym: uracil,2,4-dihydroxypyrimidine,2,4 1h,3h-pyrimidinedione,2,4-pyrimidinediol,2,4-dioxopyrimidine,pyrimidine-2,4 1h,3h-dione,pirod,2,4-pyrimidinedione,pyrod,hybar x PubChem CID: 1174 ChEBI: CHEBI:17568 IUPAC-Name: 1H-Pyrimidin-2,4-Dion SMILES: O=C1NC=CC(=O)N1

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InChI-Schlüssel	ISAKRJDGNUQOIC-UHFFFAOYSA-N
IUPAC-Name	1H-Pyrimidin-2,4-Dion
PubChem CID	1174
CAS	66-22-8
ChEBI	CHEBI:17568
MDL-Nummer	MFCD00006016
Molekulargewicht (g/mol)	112.09
SMILES	O=C1NC=CC(=O)N1
Synonym	uracil,2,4-dihydroxypyrimidine,2,4 1h,3h-pyrimidinedione,2,4-pyrimidinediol,2,4-dioxopyrimidine,pyrimidine-2,4 1h,3h-dione,pirod,2,4-pyrimidinedione,pyrod,hybar x
Summenformel	C4H4N2O2

Thiaminhydrochlorid, 99 % (Trockengewicht), kann bis zu 5 % Wasser enthalten, Thermo Scientific Chemicals

CAS: 67-03-8 Summenformel: C12H18Cl2N4OS Molekulargewicht (g/mol): 337.263 MDL-Nummer: MFCD00012780 InChI-Schlüssel: DPJRMOMPQZCRJU-UHFFFAOYSA-M Synonym: thiamine hydrochloride,vitamin b1 hydrochloride,thiamine hcl,aneurine hydrochloride,berin,thiamine chloride hydrochloride,trophite,thiamin chloride,thiamine dichloride,thiaminium chloride PubChem CID: 6202 ChEBI: CHEBI:49105 IUPAC-Name: 2-[3-[(4-Amino-2-Methylpyrimidin-5-yl)Methyl]-4-Methyl-1,3-Thiazol-3-ium-5-yl]Ethanol;Chlorid;Hydrochlorid SMILES: CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO.Cl.[Cl-]

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InChI-Schlüssel	DPJRMOMPQZCRJU-UHFFFAOYSA-M
IUPAC-Name	2-[3-[(4-Amino-2-Methylpyrimidin-5-yl)Methyl]-4-Methyl-1,3-Thiazol-3-ium-5-yl]Ethanol;Chlorid;Hydrochlorid
PubChem CID	6202
CAS	67-03-8
ChEBI	CHEBI:49105
MDL-Nummer	MFCD00012780
Molekulargewicht (g/mol)	337.263
SMILES	CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO.Cl.[Cl-]
Synonym	thiamine hydrochloride,vitamin b1 hydrochloride,thiamine hcl,aneurine hydrochloride,berin,thiamine chloride hydrochloride,trophite,thiamin chloride,thiamine dichloride,thiaminium chloride
Summenformel	C12H18Cl2N4OS

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Guanin, ≥ 99 %, Thermo Scientific Chemicals

CAS: 73-40-5 Summenformel: C5H5N5O Molekulargewicht (g/mol): 151.13 MDL-Nummer: MFCD00071533 InChI-Schlüssel: UYTPUPDQBNUYGX-UHFFFAOYSA-N Synonym: guanine,2-amino-6-hydroxypurine,guanin,2-aminohypoxanthine,mearlmaid,pearl essence,guanine enol,stella polaris,dew pearl,natural pearl essence PubChem CID: 764 ChEBI: CHEBI:16235 IUPAC-Name: 2-Amino-3,7-Dihydropurin-6-on SMILES: NC1=NC(=O)C2=C(N1)N=CN2

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InChI-Schlüssel	UYTPUPDQBNUYGX-UHFFFAOYSA-N
IUPAC-Name	2-Amino-3,7-Dihydropurin-6-on
PubChem CID	764
CAS	73-40-5
ChEBI	CHEBI:16235
MDL-Nummer	MFCD00071533
Molekulargewicht (g/mol)	151.13
SMILES	NC1=NC(=O)C2=C(N1)N=CN2
Synonym	guanine,2-amino-6-hydroxypurine,guanin,2-aminohypoxanthine,mearlmaid,pearl essence,guanine enol,stella polaris,dew pearl,natural pearl essence
Summenformel	C5H5N5O

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5-Fluorcytosin, ≥ 99%, Thermo Scientific Chemicals

CAS: 2022-85-7 Summenformel: C4H4FN3O Molekulargewicht (g/mol): 129.09 MDL-Nummer: MFCD00006035,MFCD00179326,MFCD03547958 InChI-Schlüssel: XRECTZIEBJDKEO-UHFFFAOYSA-N Synonym: 5-fluorocytosine,flucytosine,ancotil,ancobon,flucytosin,5-fluorocystosine,fluocytosine,5-fc,5-fluorocytosin,fluorcytosine PubChem CID: 3366 ChEBI: CHEBI:5100 IUPAC-Name: 6-Amino-5-Fluor-1H-Pyrimidin-2-on SMILES: NC1=C(F)C=NC(=O)N1

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InChI-Schlüssel	XRECTZIEBJDKEO-UHFFFAOYSA-N
IUPAC-Name	6-Amino-5-Fluor-1H-Pyrimidin-2-on
PubChem CID	3366
CAS	2022-85-7
ChEBI	CHEBI:5100
MDL-Nummer	MFCD00006035,MFCD00179326,MFCD03547958
Molekulargewicht (g/mol)	129.09
SMILES	NC1=C(F)C=NC(=O)N1
Synonym	5-fluorocytosine,flucytosine,ancotil,ancobon,flucytosin,5-fluorocystosine,fluocytosine,5-fc,5-fluorocytosin,fluorcytosine
Summenformel	C4H4FN3O

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Thermo Scientific Chemicals Thiamin Hydrochlorid 98.5-101.5 %

CAS: 67-03-8 Summenformel: C₁₂H₁₇ClN₄OS·HCl Molekulargewicht (g/mol): 337.26 MDL-Nummer: MFCD00012780 InChI-Schlüssel: DPJRMOMPQZCRJU-UHFFFAOYSA-M Synonym: Thiaminhydrochlorid,Vitamin-B1-Hydrochlorid,Thiamin-HCL,Aneurin-Hydrochlorid,Thiaminchlorid-hydrochlorid,Trophit,Thiaminchlorid,Thiamin-dichlorid,Thiaminiumchlorid,thiaminium chloride PubChem CID: 6202 ChEBI: CHEBI:49105 IUPAC-Name: 2-[3-[(4-Amino-2-Methylpyrimidin-5-yl)Methyl]-4-Methyl-1,3-Thiazol-3-ium-5-yl]Ethanol;Chlorid;Hydrochlorid SMILES: CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO.Cl.[Cl-]

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InChI-Schlüssel	DPJRMOMPQZCRJU-UHFFFAOYSA-M
IUPAC-Name	2-[3-[(4-Amino-2-Methylpyrimidin-5-yl)Methyl]-4-Methyl-1,3-Thiazol-3-ium-5-yl]Ethanol;Chlorid;Hydrochlorid
PubChem CID	6202
CAS	67-03-8
ChEBI	CHEBI:49105
MDL-Nummer	MFCD00012780
Molekulargewicht (g/mol)	337.26
SMILES	CC1=C(SC=[N+]1CC2=CN=C(N=C2N)C)CCO.Cl.[Cl-]
Synonym	Thiaminhydrochlorid,Vitamin-B1-Hydrochlorid,Thiamin-HCL,Aneurin-Hydrochlorid,Thiaminchlorid-hydrochlorid,Trophit,Thiaminchlorid,Thiamin-dichlorid,Thiaminiumchlorid,thiaminium chloride
Summenformel	C₁₂H₁₇ClN₄OS·HCl

4,6-Dihydroxy-2-Mercaptopyrimidin, 98 %, Thermo Scientific Chemicals

CAS: 504-17-6 Summenformel: C4H4N2O2S Molekulargewicht (g/mol): 144.15 MDL-Nummer: MFCD00006674 InChI-Schlüssel: RVBUGGBMJDPOST-UHFFFAOYSA-N Synonym: 2-thiobarbituric acid,thiobarbituric acid,bathyran,austranal,4,6-dihydroxy-2-thiopyrimidine,2-thioxodihydropyrimidine-4,6 1h,5h-dione,2-thio-4,6-dioxypyrimidine,usaf ek-660,4,6 1h,5h-pyrimidinedione, dihydro-2-thioxo,2-mercaptobarbituric acid PubChem CID: 2723628 ChEBI: CHEBI:33202 IUPAC-Name: 2-Sulfanyliden-1,3-diazinan-4,6-dion SMILES: O=C1CC(=O)NC(=S)N1

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InChI-Schlüssel	RVBUGGBMJDPOST-UHFFFAOYSA-N
IUPAC-Name	2-Sulfanyliden-1,3-diazinan-4,6-dion
PubChem CID	2723628
CAS	504-17-6
ChEBI	CHEBI:33202
MDL-Nummer	MFCD00006674
Molekulargewicht (g/mol)	144.15
SMILES	O=C1CC(=O)NC(=S)N1
Synonym	2-thiobarbituric acid,thiobarbituric acid,bathyran,austranal,4,6-dihydroxy-2-thiopyrimidine,2-thioxodihydropyrimidine-4,6 1h,5h-dione,2-thio-4,6-dioxypyrimidine,usaf ek-660,4,6 1h,5h-pyrimidinedione, dihydro-2-thioxo,2-mercaptobarbituric acid
Summenformel	C4H4N2O2S

2,4-Dihydroxypyrimidin-5-carbonsäure, 98 %, Thermo Scientific Chemicals

CAS: 23945-44-0 Summenformel: C₅H₄N₂O₄ Molekulargewicht (g/mol): 156.1 MDL-Nummer: MFCD00149397 InChI-Schlüssel: ZXYAAVBXHKCJJB-UHFFFAOYSA-N Synonym: 2,4-dihydroxypyrimidine-5-carboxylic acid,uracil 5-carboxylic acid,isoorotic acid,uracil-5-carboxylic acid,5-carboxyuracil,2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid,2,4-dihydroxy-5-pyrimidinecarboxylic acid,5-uracilcarboxylic acid,5-pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo,uracil 5-carboxylate PubChem CID: 90301 ChEBI: CHEBI:17477 IUPAC-Name: 2,4-Dioxo-1H-Pyrimidin-5-Carbonsäure SMILES: C1=C(C(=O)NC(=O)N1)C(=O)O

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InChI-Schlüssel	ZXYAAVBXHKCJJB-UHFFFAOYSA-N
IUPAC-Name	2,4-Dioxo-1H-Pyrimidin-5-Carbonsäure
PubChem CID	90301
CAS	23945-44-0
ChEBI	CHEBI:17477
MDL-Nummer	MFCD00149397
Molekulargewicht (g/mol)	156.1
SMILES	C1=C(C(=O)NC(=O)N1)C(=O)O
Synonym	2,4-dihydroxypyrimidine-5-carboxylic acid,uracil 5-carboxylic acid,isoorotic acid,uracil-5-carboxylic acid,5-carboxyuracil,2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid,2,4-dihydroxy-5-pyrimidinecarboxylic acid,5-uracilcarboxylic acid,5-pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-2,4-dioxo,uracil 5-carboxylate
Summenformel	C₅H₄N₂O₄

2-Aminopyrimidin 99 %, Thermo Scientific Chemicals

CAS: 109-12-6 Summenformel: C4H5N3 Molekulargewicht (g/mol): 95.11 MDL-Nummer: MFCD00006089 InChI-Schlüssel: LJXQPZWIHJMPQQ-UHFFFAOYSA-N Synonym: 2-aminopyrimidine,2-pyrimidinamine,pyrimidin-2-ylamine,pyrimidinamine,aminopyrimidine,2-pyrimidiylamine,pyrimidine, 2-amino,2-pyridiylamine,1,2-dihydro-2-iminopyrimidine,pyrimidine, amino PubChem CID: 7978 ChEBI: CHEBI:38618 IUPAC-Name: Pyrimidin-2-Amin SMILES: NC1=NC=CC=N1

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InChI-Schlüssel	LJXQPZWIHJMPQQ-UHFFFAOYSA-N
IUPAC-Name	Pyrimidin-2-Amin
PubChem CID	7978
CAS	109-12-6
ChEBI	CHEBI:38618
MDL-Nummer	MFCD00006089
Molekulargewicht (g/mol)	95.11
SMILES	NC1=NC=CC=N1
Synonym	2-aminopyrimidine,2-pyrimidinamine,pyrimidin-2-ylamine,pyrimidinamine,aminopyrimidine,2-pyrimidiylamine,pyrimidine, 2-amino,2-pyridiylamine,1,2-dihydro-2-iminopyrimidine,pyrimidine, amino
Summenformel	C4H5N3

Sonderaktionen verfügbar

Guanosin, 99 %, Thermo Scientific Chemicals

CAS: 118-00-3 Summenformel: C10H13N5O5 Molekulargewicht (g/mol): 283.24 MDL-Nummer: MFCD00010182 InChI-Schlüssel: NYHBQMYGNKIUIF-UUOKFMHZSA-N Synonym: guanosine,guanine riboside,vernine,guanozin,guanosin,inosine, 2-amino,usaf cb-11,vernine van,l-guanosine,9-beta-d-ribofuranosylguanine PubChem CID: 6802 ChEBI: CHEBI:16750 SMILES: NC1=NC2=C(N=CN2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(=O)N1

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InChI-Schlüssel	NYHBQMYGNKIUIF-UUOKFMHZSA-N
PubChem CID	6802
CAS	118-00-3
ChEBI	CHEBI:16750
MDL-Nummer	MFCD00010182
Molekulargewicht (g/mol)	283.24
SMILES	NC1=NC2=C(N=CN2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(=O)N1
Synonym	guanosine,guanine riboside,vernine,guanozin,guanosin,inosine, 2-amino,usaf cb-11,vernine van,l-guanosine,9-beta-d-ribofuranosylguanine
Summenformel	C10H13N5O5

5-Ioduracil, 97 %, Thermo Scientific Chemicals

CAS: 696-07-1 Summenformel: C4H3IN2O2 Molekulargewicht (g/mol): 237.98 MDL-Nummer: MFCD00006020 InChI-Schlüssel: KSNXJLQDQOIRIP-UHFFFAOYSA-N Synonym: 5-iodouracil,5-iodopyrimidine-2,4 1h,3h-dione,2,4 1h,3h-pyrimidinedione, 5-iodo,uracil, 5-iodo,5-iodopyrimidine-2,4-diol,2,4-dihydroxy-5-iodopyrimidine,5-iodo uracil,unii-h59brk500m,chembl1173,5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione PubChem CID: 69672 ChEBI: CHEBI:43636 IUPAC-Name: 5-Iod-1H-Pyrimidin-2,4-Dion SMILES: IC1=CNC(=O)NC1=O

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InChI-Schlüssel	KSNXJLQDQOIRIP-UHFFFAOYSA-N
IUPAC-Name	5-Iod-1H-Pyrimidin-2,4-Dion
PubChem CID	69672
CAS	696-07-1
ChEBI	CHEBI:43636
MDL-Nummer	MFCD00006020
Molekulargewicht (g/mol)	237.98
SMILES	IC1=CNC(=O)NC1=O
Synonym	5-iodouracil,5-iodopyrimidine-2,4 1h,3h-dione,2,4 1h,3h-pyrimidinedione, 5-iodo,uracil, 5-iodo,5-iodopyrimidine-2,4-diol,2,4-dihydroxy-5-iodopyrimidine,5-iodo uracil,unii-h59brk500m,chembl1173,5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione
Summenformel	C4H3IN2O2

4-Aminopyrimidin, 98 %, Thermo Scientific Chemicals

CAS: 591-54-8 Summenformel: C4H5N3 Molekulargewicht (g/mol): 95.105 MDL-Nummer: MFCD00006112 InChI-Schlüssel: OYRRZWATULMEPF-UHFFFAOYSA-N Synonym: 4-aminopyrimidine,4-pyrimidinamine,4-pyrimidineamine,pyrimidin-4-ylamine,pyrimidine, 4-amino,6-aminopyrimidine,4-amino pyrimidine,pyrimidine-4-ylamine,pyrimidin-4-yl-amine,4-pyrimidinamine 9ci PubChem CID: 68958 ChEBI: CHEBI:38616 IUPAC-Name: Pyrimidin-4-Amin SMILES: C1=CN=CN=C1N

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InChI-Schlüssel	OYRRZWATULMEPF-UHFFFAOYSA-N
IUPAC-Name	Pyrimidin-4-Amin
PubChem CID	68958
CAS	591-54-8
ChEBI	CHEBI:38616
MDL-Nummer	MFCD00006112
Molekulargewicht (g/mol)	95.105
SMILES	C1=CN=CN=C1N
Synonym	4-aminopyrimidine,4-pyrimidinamine,4-pyrimidineamine,pyrimidin-4-ylamine,pyrimidine, 4-amino,6-aminopyrimidine,4-amino pyrimidine,pyrimidine-4-ylamine,pyrimidin-4-yl-amine,4-pyrimidinamine 9ci
Summenformel	C4H5N3

2-Aminopyrimidin, 98 %, Thermo Scientific Chemicals

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InChI-Schlüssel	LJXQPZWIHJMPQQ-UHFFFAOYSA-N
IUPAC-Name	Pyrimidin-2-Amin
PubChem CID	7978
CAS	109-12-6
ChEBI	CHEBI:38618
MDL-Nummer	MFCD00006089
Molekulargewicht (g/mol)	95.11
SMILES	NC1=NC=CC=N1
Synonym	2-aminopyrimidine,2-pyrimidinamine,pyrimidin-2-ylamine,pyrimidinamine,aminopyrimidine,2-pyrimidiylamine,pyrimidine, 2-amino,2-pyridiylamine,1,2-dihydro-2-iminopyrimidine,pyrimidine, amino
Summenformel	C4H5N3

6-Chlor-7-deazapurin, 97 %, Thermo Scientific Chemicals

CAS: 3680-69-1 Summenformel: C₆H₄ClN₃ Molekulargewicht (g/mol): 153.57 InChI-Schlüssel: BPTCCCTWWAUJRK-UHFFFAOYSA-N Synonym: 4-chloro-7h-pyrrolo 2,3-d pyrimidine,4-chloropyrrolo 2,3-d pyrimidine,6-chloro-7-deazapurine,4-chloro-1h-pyrrolo 2,3-d pyrimidine,7h-pyrrolo 2,3-d pyrimidine, 4-chloro,1h-pyrrolo 2,3-d pyrimidine, 4-chloro,6-chloro-7-deazapurine 4-chloro-1h-pyrrolo 2,3-d pyrimidine,4-chloro-1h-pyrrol 2,3-d pyrimidine PubChem CID: 5356682 IUPAC-Name: 4-Chlor-7H-Pyrrolo[2,3-d]Pyrimidin SMILES: C1=CNC2=C1C(=NC=N2)Cl

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InChI-Schlüssel	BPTCCCTWWAUJRK-UHFFFAOYSA-N
IUPAC-Name	4-Chlor-7H-Pyrrolo[2,3-d]Pyrimidin
PubChem CID	5356682
CAS	3680-69-1
Molekulargewicht (g/mol)	153.57
SMILES	C1=CNC2=C1C(=NC=N2)Cl
Synonym	4-chloro-7h-pyrrolo 2,3-d pyrimidine,4-chloropyrrolo 2,3-d pyrimidine,6-chloro-7-deazapurine,4-chloro-1h-pyrrolo 2,3-d pyrimidine,7h-pyrrolo 2,3-d pyrimidine, 4-chloro,1h-pyrrolo 2,3-d pyrimidine, 4-chloro,6-chloro-7-deazapurine 4-chloro-1h-pyrrolo 2,3-d pyrimidine,4-chloro-1h-pyrrol 2,3-d pyrimidine
Summenformel	C₆H₄ClN₃

2-Methylpyrimidin-5-carbonsäure, 97 %, Thermo Scientific Chemicals

CAS: 5194-32-1 Summenformel: C6H6N2O2 Molekulargewicht (g/mol): 138.126 MDL-Nummer: MFCD08235210 InChI-Schlüssel: NMGIXZFBQPETOK-UHFFFAOYSA-N Synonym: 2-methyl-5-pyrimidinecarboxylic acid,2-methylpyrimidine-5-carboxylicacid,5-pyrimidinecarboxylic acid, 2-methyl,2-methyl-5-pyrimidinecarboxylicacid,pubchem13290,acmc-209kwu,ksc269i7t,2-methyl-pyrimidine-5-carboxylic acid,5-pyrimidinecarboxylicacid, 2-methyl,2-methyl pyrimidine-5-carboxylic acid PubChem CID: 13670875 IUPAC-Name: 2-Methylpyrimidin-5-Carbonsäure SMILES: CC1=NC=C(C=N1)C(=O)O

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InChI-Schlüssel	NMGIXZFBQPETOK-UHFFFAOYSA-N
IUPAC-Name	2-Methylpyrimidin-5-Carbonsäure
PubChem CID	13670875
CAS	5194-32-1
MDL-Nummer	MFCD08235210
Molekulargewicht (g/mol)	138.126
SMILES	CC1=NC=C(C=N1)C(=O)O
Synonym	2-methyl-5-pyrimidinecarboxylic acid,2-methylpyrimidine-5-carboxylicacid,5-pyrimidinecarboxylic acid, 2-methyl,2-methyl-5-pyrimidinecarboxylicacid,pubchem13290,acmc-209kwu,ksc269i7t,2-methyl-pyrimidine-5-carboxylic acid,5-pyrimidinecarboxylicacid, 2-methyl,2-methyl pyrimidine-5-carboxylic acid
Summenformel	C6H6N2O2

Pyrimidin-5-carbonsäure, 95 %, Thermo Scientific Chemicals

CAS: 4595-61-3 Summenformel: C5H4N2O2 Molekulargewicht (g/mol): 124.10 MDL-Nummer: MFCD00856162 InChI-Schlüssel: IIVUJUOJERNGQX-UHFFFAOYSA-N Synonym: 5-pyrimidinecarboxylic acid,5-carboxypyrimidine,pyrimidine-5-carboxilic acid,5-pyrimidine carboxylic acid,pyrimidine-5-carboxylate acid,pyrimidine-5-carboxylicacid,pubchem2056,acmc-209k5a,5-pyrimidyl carboxylic acid,pyrimidin-5-carboxylic acid PubChem CID: 78346 IUPAC-Name: Pyrimidin-5-Carbonsäure SMILES: OC(=O)C1=CN=CN=C1

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InChI-Schlüssel	IIVUJUOJERNGQX-UHFFFAOYSA-N
IUPAC-Name	Pyrimidin-5-Carbonsäure
PubChem CID	78346
CAS	4595-61-3
MDL-Nummer	MFCD00856162
Molekulargewicht (g/mol)	124.10
SMILES	OC(=O)C1=CN=CN=C1
Synonym	5-pyrimidinecarboxylic acid,5-carboxypyrimidine,pyrimidine-5-carboxilic acid,5-pyrimidine carboxylic acid,pyrimidine-5-carboxylate acid,pyrimidine-5-carboxylicacid,pubchem2056,acmc-209k5a,5-pyrimidyl carboxylic acid,pyrimidin-5-carboxylic acid
Summenformel	C5H4N2O2

Pyrimidine und Derivate

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